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Drug ReportsAntihemophilic factor
Antihemophilic factor
Antihemophilic factor is an unknown pharmaceutical. It is currently being investigated in clinical studies.
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Events Timeline
Commercial
Clinical
Drug
Target
Variants
Financial
Trends
Safety
Events Timeline
5D
1M
3M
6M
YTD
1Y
2Y
5Y
Max
Events
FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
Start date
Primary completion date
Completion date
Results first post date
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Mock data
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Commercial
Therapeutic Areas
No data
Trade Name
FDA
EMA
Adynovate, Afstyla, Altuviiio, Eloctate, Esperoct, Hemofil m, Jivi, Koate, koate-dvi, Kovaltry, Obizur (discontinued: Monoclate, monoclate-p)
Combinations
Advate, Alphanate, Humate-p, Xyntha, xyntha solofuse
Drug Products
FDA
EMA
Reference product - 351(a)
Reference product - 351(a)
Interchangeable product - 351(k)
Interchangeable product - 351(k)
Biosimilar product - 351(k)
Biosimilar product - 351(k)
Antihemophilic factor (human)
Tradename
Proper name
Company
Number
Date
Products
Koate, Koate-DviAntihemophilic Factor (Human)GrifolsA-101130 RX1974-01-24
3 products
Hemofil MAntihemophilic Factor (Human)TakedaA-101448 RX2001-03-14
4 products
Show 1 discontinued
Albumin free method
+
Antihemophilic factor (recombinant)
+
plasma
Tradename
Proper name
Company
Number
Date
Products
AdvateAntihemophilic Factor (Recombinant), Plasma/Albumin Free MethodTakedaA-125063 RX2003-07-25
7 products
Albumin free
+
Antihemophilic factor (recombinant)
+
plasma
Tradename
Proper name
Company
Number
Date
Products
Xyntha, Xyntha SolofuseAntihemophilic Factor (Recombinant), Plasma/Albumin FreeWyethA-125264 RX2008-02-21
9 products
Antihemophilic factor (recombinant)
+
fc fusion protein
Tradename
Proper name
Company
Number
Date
Products
EloctateAntihemophilic Factor (Recombinant), Fc Fusion proteinBioverativA-125487 RX2014-06-06
10 products
Antihemophilic factor (recombinant)
+
porcine sequence
Tradename
Proper name
Company
Number
Date
Products
ObizurAntihemophilic Factor (Recombinant), Porcine SequenceTakedaA-125512 RX2014-10-23
1 products
Antihemophilic factor (recombinant)
+
pegylated
Tradename
Proper name
Company
Number
Date
Products
JiviAntihemophilic factor (recombinant), PEGylated-auclBayerA-125661 RX2018-08-29
4 products
JiviAntihemophilic factor (recombinant), PEGylated-auclBayerN-125661 RX2024-12-02
1 products
AdynovateAntihemophilic Factor (Recombinant), PEGylatedTakedaA-125566 RX2015-11-13
7 products
Antihemophilic factor (recombinant)
+
full length
Tradename
Proper name
Company
Number
Date
Products
KovaltryAntihemophilic Factor (Recombinant), Full LengthBayerA-125574 RX2016-03-16
5 products
Antihemophilic factor (recombinant)
+
single chain
Tradename
Proper name
Company
Number
Date
Products
AfstylaAntihemophilic Factor (Recombinant), Single ChainCSL BehringA-125591 RX2016-05-25
7 products
Antihemophilic factor (recombinant)
+
glycopegylated
Tradename
Proper name
Company
Number
Date
Products
EsperoctAntihemophilic Factor (Recombinant), GlycoPEGylated-exeiNovo NordiskA-125671 RX2019-02-19
5 products
Antihemophilic factor (recombinant)
+
fc-vwf-xten fusion protein
Tradename
Proper name
Company
Number
Date
Products
ALTUVIIIOantihemophilic factor (recombinant), Fc-VWF-XTEN fusion protein-ehtlBioverativN-125771 RX2023-02-22
7 products
Antihemophilic factor
+
Von willebrand factor complex (human)
Tradename
Proper name
Company
Number
Date
Products
Humate-PAntihemophilic Factor/von Willebrand Factor Complex (Human)CSL BehringA-103960 RX2000-04-11
3 products
AlphanateAntihemophilic Factor/von Willebrand Factor Complex (Human)GrifolsA-102475 RX1978-08-15
5 products
Labels
FDA
EMA
Brand Name
Status
Last Update
alphanateBiologic Licensing Application2010-10-07
altuviiioBiologic Licensing Application2025-03-11
hemofil mBiologic Licensing Application2011-03-15
humate-pBiologic Licensing Application2010-01-14
recombinateExport only2010-05-26
von willebrand factor/coagulation factor viii complex (human)Biologic Licensing Application2010-08-20
xynthaBiologic Licensing Application2011-01-13
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
No data
HCPCS
Code
Description
J7180
Injection, factor xiii (antihemophilic factor, human), 1 i.u.
J7182
Injection, factor viii, (antihemophilic factor, recombinant), (novoeight), per iu
J7185
Injection, factor viii (antihemophilic factor, recombinant) (xyntha), per i.u.
J7186
Injection, antihemophilic factor viii/von willebrand factor complex (human), per factor viii i.u.
J7188
Injection, factor viii (antihemophilic factor, recombinant), (obizur), per i.u.
J7189
Factor viia (antihemophilic factor, recombinant), (novoseven rt), 1 microgram
J7190
Factor viii (antihemophilic factor, human) per i.u.
J7191
Factor viii (antihemophilic factor (porcine)), per i.u.
J7192
Factor viii (antihemophilic factor, recombinant) per i.u., not otherwise specified
J7193
Factor ix (antihemophilic factor, purified, non-recombinant) per i.u.
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Clinical
Clinical Trials
543 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Hemophilia aD006467EFO_0007267D66666113368192486
Hemophilia bD002836—D67891842559
Blood coagulation disordersD001778EFO_0009314D68.9521231535
Hemostatic disordersD020141——53831128
Von willebrand diseasesD014842EFO_0003910D68.023144426
HemorrhageD006470MP_0001914R58——431118
Hematologic diseasesD006402EFO_0005803D75.92232512
Coagulation protein disordersD020147——114139
Inherited blood coagulation disordersD025861——112137
Joint diseasesD007592—M12.9———257
Show 15 more
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Hemorrhagic disordersD006474—D69.9113—48
Inborn genetic diseasesD030342EFO_0000508—112—25
Type 3 von willebrand diseaseD056729Orphanet_166096D68.032—1—25
X-linked genetic diseasesD040181——111—13
Bone diseasesD001847—M89.9——1——1
Acquired immunodeficiency syndromeD000163EFO_0000765B20——1——1
Aids-related complexD000386EFO_0007137B20——1——1
Sexual behaviorD012725————1——1
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Healthy volunteers/patients———41———5
Genetic therapyD015316——22——13
Systemic sclerodermaD012595EFO_0000717M34—1———1
Raynaud diseaseD011928EFO_1001145I73.0—1———1
Brain neoplasmsD001932EFO_0003833C71—1———1
GlioblastomaD005909EFO_0000515——1———1
DependovirusD000229——11———1
Gene transfer techniquesD018014——11———1
HemostasisD006487———1———1
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Factor vii deficiencyD005168—D68.22————2
Cardiovascular diseasesD002318EFO_0000319I981————1
MenorrhagiaD008595EFO_0003945N92.01————1
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Multiple sclerosisD009103EFO_0003885G35————33
SclerosisD012598——————33
Motor activityD009043EFO_0003940—————33
Sickle cell anemiaD000755EFO_0000697D57————22
ThrombosisD013927——————22
InfertilityD007246EFO_0000545—————22
Breast neoplasmsD001943EFO_0003869C50————11
SeromaD049291——————11
Relapsing-remitting multiple sclerosisD020529EFO_0003929—————11
Replacement arthroplastyD019643——————11
Show 51 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameAntihemophilic factor
INN—
Description
Alphanate (antihemophilic factor) is a protein pharmaceutical. It is a lyophilized concentrate of Factor VIII (FVIII; AHF) and von Willebrand Factor (VWF).
Classification
Protein
Drug class—
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
>4KI5:C|MURINE MONOCLONAL 3E6 FAB HEAVY CHAIN QIQLVQSGPELKKPGKTVKISCKASDYTFTDYSLHWVKQAPGKGLKWMGWINTETGDPAYADDFKGRFAFSLETSVRTAY LQINNLKNEDTAIYFCAREDDGLASWGQGTTLTVSSAKTTAPSVYPLAPVCGDTTGSSVTLGCLVKGYFPEPVTLTWNSG SLSSGVHTFPAVLQSDLYTLSSSVTVTSSTWPSQSITCNVAHPASSTKVDKKIEPRGPA >4KI5:D|MURINE MONOCLONAL 3E6 FAB LIGHT CHAIN QIVLTQSPAIMSASPGEKVTMTCSASSTVSYMYWYQQKPGSSPRFLISDTSNLASGVPVRFSGSGSGTSYSLTISRIEAE DAATYYCQHWSSYPLTFGGGTKLELKRADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLN SWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNRNEC >4KI5:E|MURINE MONOCLONAL G99 FAB HEAVY CHAIN QVQLQQSGAELMKPGASVKISCKATGYTFSSYWIEWVKQRPGHGLEWIGEILPGSGSTNYNERFKGKASFTADSSSNTAY MQLSSLTSEDSAVYYCTRTSYYFGSSYDFDVWGAGTTVTVSSAKTTAPSVYPLAPVCGDTTGSSVTLGCLVKGYFPEPVT LTWNSGSLSSGVHTFPALLQSDLYTLSSSVTVTSSTWPSQSITCNVAHPASSTKVDKKIEPRGP >4KI5:F|MURINE MONOCLONAL G99 FAB LIGHT CHAIN DIQMTQSPSSLSASLGERVSLTCRASQEISGYLSWLQQKPDGTIKRLIYAASTLDSSVPKRFSGSRSGSDYSLTISSLDS EDFAVYYCLQYASYPYTFGGGTKVEIKRADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVL NSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNRNEC >4KI5:M|Coagulation factor VIII MGSSHHHHHHSSGLVPRGSHMLNSCSMPLGMESKAISDAQITASSYFTNMFATWSPSKARLHLQGRSNAWRPQVNNPKEW LQVDFQKTMKVTGVTTQGVKSLLTSMYVKEFLISSSQDGHQWTLFFQNGKVKVFQGNQDSFTPVVNSLDPPLLTRYLRIH PQSWVHQIALRMEVLGCEAQDLY
Identifiers
PDB3CDZ, 3HNB, 3J2Q, 3J2S, 4BDV, 4KI5, 4PT6, 4XZU, 5K8D, 6MF0, 6MF2, 7K66, 7KBT
CAS-ID—
RxCUI—
ChEMBL IDCHEMBL2108175
ChEBI ID—
PubChem CID—
DrugBank—
UNII ID—
Target
No data
Variants
No data
Financial
Revenue by drug
$
€
£
â‚£
Advate – Takeda
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Eloctate – Sanofi
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Altuviiio – Sanofi
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Adynovate – Takeda
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Estimated US medical usage
Antihemophilic factor
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Refill frequency
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Price per prescription (USD)
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Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 1,268 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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15,906 adverse events reported
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